Chad Tatko

Chad Tatko


  • B.S., Wheaton College, 1998
  • Ph.D., University of North Carolina-Chapel Hill, Organic Chemistry, 2004

Thesis: The Thermodynamic and Geometric Impact of Noncovalent Interactions on Elements of Secondary Structure
Advisor: Marcey L. Waters

Professional experience

  • Associate Professor of Chemistry, Calvin University (College), 2012-present
  • Assistant Professor of Chemistry, Calvin University (College), 2006-2012
  • NIH Post-doctoral Associate, University of Pennsylvania, 2005-2006
  • NIH Cancer Fellow, University of Pennsylvania, 2004-2005

Research and scholarship


Undergraduate student names appear in bold

Swartz, M.A.; Tubergen, P.J.; Tatko, C.D.; Baker, R.A. “Experimental Determination of pKa Values and Metal Binding for Biomolecular Compounds Using 31P NMR Spectroscopy” Journal of Chemical Education, 95, 1, 182-185, 2018

Veldkamp, K.L.; Tubergen, P.J.; Swartz, M.A.; DeVries, J.T.; Tatko, C.D. “Zinc Binding with L-Dopa Peptides” Inorganica Chimica Acta, 461, 120-126, 2017.

Meyer, D.; Mutschler, C.; Robertson, I.; Batt, A.; Tatko, C.D.; “Aromatic Interactions with Naphthylalanine in a −Hairpin Peptide” Journal of Peptide Science, 19, 277-282, 2013. 

Morris, G.; Robertson, I.; Tatko, C.D. “Iron Binding -Hairpin Peptides” BioMetals, 26, 5, 667-675, 2013. 

Uitvlugt, C.J.; Sung, J.; Mutschler, C.M.; Meyer, D.B.; Tatko, C.D. “Aromatic Interactions of Naphthylalanine in a Twelve Amino Acid Peptide” Journal of Undergraduate Chemistry Research, 11, 3 94-97, 2012

Nguyen, P.A.; Soto, C.S.; Polishchuk, A.; Caputo, G.A.; Tatko, C.D.; Ma, C.; Ohigashi, Y.; Pinto, L.H.; DeGrado, W.F.; Howard, K.P. “pH-Induced Conformational Change of the Influenza M2 Protein C-Terminal Domain” Biochemistry, 47, 9934-9936, 2008

Tatko, C.D. “Sugars Stack Up” Nature Chemical Biology, 4, 586-587, 2008. 

Cady, S.D., C. Goodman, C.D. Tatko, W.F. DeGrado, M. Hong. “Determining the Orientation of Uniaxially Rotating Membrane Proteins Using Unoriented Samples: a 2H, 13C, and 15N solid-state NMR Investigation of the Dynamics and Orientation of a Transmembrane Helical Bundle.” Journal of the American Chemical Society 129, 5719-5729, 2007. 

Kinsinger, C. R.; Tatko, C. D.; Whelan, C. M.; Wilkinson, T. J. “Synthesis of 4-Substituted- and 1,4-Disubstitutited-4-Hydroxypyrrolidin-2-ones” Synthetic Communication, 37, 1845-1852, 2007

C.D. Tatko, V. Nanda, J.D. Lear, W.F. DeGrado. “Polar Interactions Control Oligomeric Assembly in Membranes.” Journal of the American Chemical Society, 128, 4170-4171. 2006

C.D. Tatko, M.L. Waters. “Effect of Halogenation on Edge-Face Aromatic Interactions in a β-Hairpin Peptide: Enhanced Affinity with Iodo-Substituents.” Organic Letters, 6, 3969-3972. 201, 2004.

C.D. Tatko, M.L. Waters. “Investigation of the Nature of the Methionine-π Interaction in a β-Hairpin peptide Model System.” Protein Science, 13, 2515-2522, 2004

C.D. Tatko, M.L. Waters. “Comparison of C-H···π and Hydrophobic Interactions in a β-Hairpin Peptide: Impact on Stability and Specificity.” Journal of the American Chemical Society, 126, 2028-2034, 2004.

Learn more about Calvin's excellent faculty and learning environment by scheduling a campus visit.

Visit »

  • Course code:
  • Credits:
  • Semester:
  • Department: