Carolyn E. Anderson
- BSC, University of Michigan, Ann Arbor, 1998
- PhD, University of California-Irvine, Organic Chemistry, 2003
- Director of Calvin Core, Calvin University, 2021- present
- Department of Chemistry and Biochemistry Co-Chair, Calvin University, 2020- present
- Professor of Chemistry, Calvin University, 2018- present
- Associate Professor of Chemistry, Calvin University (College), 2013-2018
- Assistant Professor of Chemistry, Calvin University (College), 2006-2013
- Dreyfus Post-doctoral Fellow, Pomona College, 2004-2006
Professor Anderson grew up in suburban Detroit and earned her B.S. in Chemistry from the University of Michigan. After an extended internship at Pharmacia and Upjohn Corporation in Kalamazoo, MI, she pursued her graduate degree in synthetic organic chemistry at the University of California – Irvine. After completing a teaching post-doctoral fellowship at Pomona College, Professor Anderson joined the faculty of Calvin University (formally 'College') in 2006, where she has risen through the ranks, becoming full professor in 2018. When she is not developing new methods for the synthesis of unique nitrogen heterocycles, Professor Anderson like to read and play games with her husband and their three kids.
Even as a 10-year-old girl, Carolyn Anderson knew what she wanted to do with her life.
"When I was 10, my uncle got married to a woman, Heather, who was just starting her PhD in epidemiology,” said Anderson, a chemistry professor at Calvin College. “Heather sent me lots of pop-science, you know, ‘What is in the potato salad?’ Kind of epidemiological mysteries if you will … I thought that was the coolest stuff ever.”
- Synthesis of nitrogen heterocycles
- Developing the next generation of scientists and future PUI faculty
- Promoting Diversity and Inclusion of those from historically underrepresented group in STEM and across the academy
Research and scholarship
Professor Anderson’s research efforts involve developing facile methods for the synthesis and application of N-alkyl pyridones. N-Alkyl pyridones are interesting motifs due to their prevalence in natural products as well as their ability to serve as biological mimics in pharmaceutical targets. Projects in the group include: optimization of new organic and organometallic reactions, evaluation of reaction scope, and mechanistic studies.
Undergraduate student names appear in bold.
Hartgerink, C. T.; Staples, R. J.; Anderson, C. E. "Crystal structure of tris(2-dicyclohexylphosphino-2’6’-dimethoxy-1,1’-biphenyl-kP)-m-oxoethenylidene-triangulo-trigold(I) bis(trifluoromethanesulfonyl)imide". Acta Cryst. 2021, E77, 537-541.
Romero, E. O.; Reidy, C. P.; Bootsma, A. N.; PreFontaine, N. M.; Vryhof, N. W.; Wierenga, D. C.; Anderson, C. E. “Correction to Synthesis of N-Alkenyl 2-Pyridonyl Ethers via a Au(I)-Catalyzed Rearrangement of 2-Propargyloxypyridines”. J. Org. Chem. 2020, 85, 3990-3991.
Rossler, M. D.; Hartgerink, C. T.; Zerull, E. E.; Boss, B. L.; Frndak, A. K.; Mason, M. M.; Nickerson, L. A.; Romero, E. O.; Van De Burg, J. E.; Staples, R. J.; Anderson, C. E. “Au(I)-Catalyzed Synthesis of Trisubstituted Indolizines from 2-Propargyloxypyridines and Methyl Ketones” Lett. 2019, 21, 5591–5595.
Hromada, S.; Hilbrands, A.; Wolf, E. M.; Ross, J. L.; Heeg, T.; Roth, A.; Hollowell, M.; Anderson, C. E.; Benson, D. E. “Protein Oxidation Involved in Cys-Tyr Post-Translational Modification” J. Inorg. Biochem. 2017, 176, 168–174.
Romero, E. O.; Reidy, C. P.; Bootsma, A. B.; PreFontaine, N. M.; Vryhof, N. W.; Wierenga, D. C.; Anderson, C. E. “Synthesis of N-Alkenyl 2-Pyridonyl Ethers via a Au(I)-Catalyzed Rearrangement of 2-Propargyloxypyridines” J. Org. Chem. 2016, 81, 9895–9902.
Bootsma, A. B.; Anderson, C. E. “Computational and Experimental Evaluation of a-(N-2-Quinolonyl)ketones: A New Class of Nonbiaryl Atropisomers” Tetrahedron Lett. 2016, 57, 4834–4837.
Tasker, S. Z.; Bosscher, M. A.; Shandro, C. A.; Lanni, E. L.; Ryu, K.-A.; Snapper, G. S.; Utter, J. M.; Ellsworth, B. A.; Anderson, C. E. “Preparation of N-Alkyl 2-Pyridones via a Lithium Iodide-Promoted O- to N-Alkyl Migration: Scope and Mechanism” J. Org. Chem. 2012, 77, 8220–8230.
Romero, N. A.; Klepser, B. M.; Anderson, C. E. “Au(III)-Catalyzed Tandem Amination-Hydration of Alkynes: Synthesis of a-(N-2-Pyridonyl)ketones” Org. Lett. 2012, 14, 874–877.
Tasker, S. Z.; Brandsen, B. M.; Ryu, K.-A.; Snapper, G. S.; Staples, R. J.; DeKock, R. L.; Anderson, C. E. “Synthesis of a New Class of b-Iodo N-Alkenyl Pyridones” Org. Lett. 2011, 13, 6224–6227.
Lanni, E.L., Bosscher, M.A., Ooms, B.D., Shandro, C.A., Ellsworth, B.A., Anderson, C.E. “Synthesis of Substituted N-Benzyl Pyridones via an O- to N-Alkyl Migration” J. Org. Chem. 73, 2008; 6425–6428. PDF
Anderson, C.E., Pickrell, A. J., Sperry, S. L., Vasquez, Jr., T. E., Custer, T. G., Fierman, M. B.; Lazar, D. C., Brown, Z.W., Iskenderian, W.S., Hickstein, D.D., O’Leary, D.J. “NMR Detection of Intramolecular OH/OH Hydrogen Bond Networks: An Approach Using Isotopic Perturbation and Hydrogen Bond Mediated OH•••OH J-Coupling” Heterocycles 72, 2007; 469–495. PDF
Anderson, C.E., Kirsch, S.F., Overman, L.E., Richards, C.J., Watson, M.P. “Preparation of the COP Catalysts: [(S)-COP-OAc]2, [(S)-COP-Cl]2, and (S)-COP-hfacac” Org. Syn. 84, 2007; 148-155. PDF
Anderson, C.E., Overman, L.E., Richards, C.J., Watson, M.P., White, N. “Preparation of (eta-5-(S)-2-(4-methylethyl)oxazolinyl)cyclopentadienyl)-(eta-4 -tetraphenylcyclobutadiene)cobalt” Org. Syn. 84, 2007;139-147. PDF
Loening, N.M., Anderson, C.E., Iskenderian, W.S., Anderson, C.D., Rychnovsky, S.D., Barfield, M., O’Leary, D.J. “Qualitative and Quantitative Measurements of Hydrogen Bond Mediated Scalar Couplings in Acyclic 1,3-Diols” Org. Lett. 8, 2006; 5321–5323. PDF
Anderson, C.E., Britt, D.K., Sangji, S., O'Leary, D.J.; Anderson, C.D., Rychnovsky, S.D. "Direct Assignment of the Relative Configuration in Acyclic 1,3-Diols by 1H NMR Spectroscopy" Org. Lett. 7, 2005; 5721–5723. PDF
Anderson, C.E., Overman, L.E., Watson, M.P. “Asymmetric Allylic Imidate Rearrangement to Allylic Amides: (S)-2,2,2-Trichloro- N-(1-propylallyl)acetamide” Org. Syn., 2005, Vol. 82; 134–139.
Anderson, C.E., Donde, Y., Douglas, C.J., Overman, L.E. “Catalytic Asymmetric Synthesis of Chiral Allylic Amines. Evaluation of Ferrocenyloxazoline Palladacyclic Catalysts and Imidate Motifs” J. Org. Chem. 70, 2005; 648–657. PDF
Prasad, R.S., Anderson, C.E., Richards, C.J., Overman, L.E. “Synthesis of tert -Leucine-Derived Cobalt Oxazoline Palladacycles. Reversal of Palladation Diastereoselectivity and Application to the Asymmetric Rearrangement of N -Aryl Trifluoroacetimidates.” Organometallics 24, 2005; 77–81. PDF
Anderson, C.E., Overman, L.E. “Catalytic Asymmetric Rearrangement of Allylic Trichloroacetimidates. A Practical Method for Preparing Allylic Amines and Congeners of High Enantiomeric Purity” J. Am. Chem. Soc. 2003, 125, 12412–12413. PDF
Overman, L.E., Owen, C.E., Pavan, M.M., Richards, C.J. "Catalytic Asymmetric Rearrangement of Allylic N -Acyl Trifluoroacetimidates. A Useful Method for Transforming Prochiral Allylic Alcohols to Chiral Allylic Amines" Org. Lett. 5, 2003; 1809–1812. PDF
Overman, L.E., Owen, C.E., Zipp, G.G. "Diastereoselective Lithiation of (eta-6 -Arene) dicarbonyltriphenylphosphane Chromium(0) Oxazoline Complexes–Direct Preparation of Enantiopure Complexes Having Planar Chiral Fragments of Either Configuration" Angew. Chem. Int. Ed. 41, 2002; 3884–3887. PDF
Herrinton, P.M., Owen, C.E., Gage, J.R. "Iodination and Metal Halogen Exchange of Aromatic Compounds: An Improved Preparation of a Key Oxazolidinone Antibiotic Intermediate" Org. Process Res. Dev. 5, 2001; 80–83. PDF
Organic Syntheses, Inc., Summer Research at an Undergraduate Institution ($8,000) - Summer 2019
National Science Foundation Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM), Building Foundations for Success in STEM (PI, $1,000,000, DUE 1833847) - February 2019 - May 2025
National Science Foundation Research at Undergraduate Institutions, RUI: Synthesis of Highly Functionalized Heterocyclic Scaffolds (PI, $299,718, CHE 1665139) - May 2017- April 2022
Calvin College Award for Student-Faculty Research - April 2016
Calvin College Funded Sabbatical - January 2016 - August 2016
National Science Foundation Research at Undergraduate Institutions, RUI: Synthesis of Highly Functionalized N-Alkyl 2-Pyridones and Their Analogues (PI, $230,000, CHE 1266314) - May 2013 - April 2017
American Chemical Society Division of Organic Chemistry Travel Award - June 2007, 2009, 2011, 2015, 2017
National Science Foundation Research at Undergraduate Institutions, RUI: Synthesis of N-Alkyl Pyridones: Mechanism, Methodology and Application to Organic Materials (PI, $170,000, CHE 0911264) - July 2009 - April 2013
Research Corporation for Science Advancement Cottrell College Science Award, Chromium Carbene-Accelerated Type II Intramolecular Diels-Alder Reactions as a Gateway to Strained Ring Libraries (PI, $36,418, #CC6840/6811) - May 2007– December 2010
American Chemical Society–Petroleum Research Fund Type G Grant, Chromium Carbene-Accelerated Type II Intramolecular Diels-Alder Reactions as a Gateway to Strained Ring Libraries (PI, $40,000, #45897-GB1) - May 2007– August 2009
Camille and Henry Dreyfus Foundation Supplemental Award of the Scholar/Fellow Program for Undergraduate Institutions (PI, $10,000, #SL-06-01) - July 2006
Wig Teaching Innovation Grant, Pomona College - August 2005
Henry and Camille Dreyfus Foundation Post-Doctoral Fellowship - July 2004
Amgen Research Fellowship in Synthetic Organic Chemistry - April 2003
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