Arlene Hoogewerf

Arlene Hoogewerf


  • BS, 1986, Calvin College. Major: Biology, Minor: Chemistry.
  • PhD, 1991, Cornell University, Nutritional Biochemistry.

Professional experience

  • UpJohn Company, Kalamazoo, MI. Post-doctoral researcher in the Cancer and Infectious Diseases Unit, 1991-1994
  • Glaxo Pharamceutical Company, Geneva, Switzerland, Post-doctoral researcher with the Chemokine Project team, 1994-1997
  • Midland Certified Reagent Company, Midland, TX. Director of Catalog Products Division, 1997-2000
  • Professor, Department of Biology, Calvin College, Grand Rapids, MI, 2000-present
  • Dean, Natural Sciences and Mathematics, 2017-2021
  • Dean, School of Science, Technology, Engineering, and Mathematics (STEM), 2021-present


Dr. Hoogewerf has taught courses in several programs. She taught Cell Biology and Genetics and Microbiology in the Biology program, Nutrition in the Health Education Program, and Epidemiology in the Public Health Program. She has a long-time interest in preventative health and the courses she taught in all of these programs are connected to this interest.  She currently is an academic dean.

Academic interests

  • assessing and analyzing nutrition environments
  • bacterial communities called biofilms
  • heavy metal resistance in bacteria
  • biotechnology
  • nutrition
  • public heatlh

Research and scholarship


  • Ubels J.L, Osmond .JM., Timmermans M.A., and Hoogewerf A.J. Prevalence of Refractive Error and Need for Corrective Lenses in Medically Underserved Residents of Tijuana, Mexico. 2019. doi:  
  • Elgin, S.C.R….RJ DeJong, A. Hoogewerf....J. Leatherman.  The GEP:  Crowd-Sourcing Big Data Analysis with Undergraduates.  Trends in Genetics 33:81-85, 2017. 
  • Leung, W…..RJ DeJong, A Hoogewerf, Cheri M. Ackerman, Isaac O. Armistead, Lara Baatenburg, Matthew J. Borr, Lindsay K. Brouwer, Brandon J. Burkhart, Kelsey T. Bushhouse, Lejla Cesko, Tiffany Y.Y. Choi, Heather Cohen, Amanda M. Damsteegt, Jess M. Darusz, Cory M. Dauphin, Yelena P. Davis, Emily J. Diekema, Melissa Drewry, Michelle E. M. Eisen, Hayley M. Faber, Katherine J. Faber, Elizabeth Feenstra, Isabella T. Felzer-Kim, Brandy L. Hammond, Jesse Hendriksma, Milton R. Herrold, Julia A. Hilbrands, Emily J. Howell, Sarah A. Jelgerhuis, Timothy R. Jelsema, Benjamin K. Johnson, Kelly K. Jones, Anna Kim, Ross D. Kooienga, Erika E. Menyes, Eric A. Nollet, Brittany E. Plescher, Lindsay Rios, Jenny L. Rose, Allison J. Schepers, Geoff Scott, Joshua R. Smith, Allison M. Sterling, Jenna C. Tenney, Chris Uitvlugt, Rachel E. Van Dyken, Marielle VanderVennen, Samantha Vue…..Elgin, SCR. The Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution. G3:  Genes, Genomes, and Genetics, March 4, 2015, doi: 10.1534/g3.114.015966 (46 Calvin College student authors) 
  • Hoogewerf, A.J., Van Dyk, L.A., Buit, T.S., Roukema, D., Resseguie, E., Plaisier, C., Le, N., Heeringa, L., and Vander Griend, D.A. Functional characterization of a cadmium resistance operon in Staphylococcus aureus ATCC12600:  CadC does not function as a repressor.  J. Basic Microbiol. 54:1-12, 2014.
  • Leung, W…..RJ DeJong…..A Hoogewerf,… al. Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution. Submitted to Genetics. Sept. 2014.
  • Lopatto D,…RJ DeJong,…A Hoogewerf, A central support system can facilitate implementation and sustainability of a classroom-based undergraduate research experience (CURE) in genomics.  CBE-Life Sciences Education, 13:1-13, 2014. DOI:  10.1187/cbe-13-10-0200
  • Shaffer, CD,…RJ DeJong,…A Hoogewerf,… A course-based research experience:  how benefits change with increased investment in instructional time.  CBE Life Sciences Education, 13:111-130, 2014.
  • McLaughlin, R.A., and Hoogewerf, A. J. Interleukin-1beta-Induced Growth Enhancement of Staphylococcus aureus Occurs in Biofilm but not Planktonic Cultures. Microbial Pathogenesis. 41:67-79, 2006.
  • June 2005 Book: Transforming Care: A Christian Vision of Nursing Practice. Edited by: Mary Molewyk Doornbos, Ruth E. Groenhout, and Kendra G. Hotz. With contributing authors: Cheryl Brandsen, Bart Cusveller, Mary Flikkema, Arlene Hoogewerf, Clarence Joldersma, and Barbara Timmermans. ( Grand Rapids , MI : Wm. B. Eerdmans Publishing, 2005).
  • Yolande Chvatchko, Arlene J. Hoogewerf, Alexandra Meyer, Sami Alouani, Pierre Juillard, Raphael Buser, Francois Conquet, Amanda E. I. Proudfoot, Timothy N. C. Wells and Christine A. Power, A key role for CCR4 in lipopolysaccharide-induced endotoxic shock, J. Exp. Med ., 191, 1755-1764, (2000).
  • Hoogewerf, A.J. and Kuschert, G.S.V.  Chemokine-glycosaminoglycan binding assays.  Chemokines, Methods Mol. Biol  138:173-177, 2000 
  • Kuschert, G.S., Coulin, F., , Proudfoot, A.E., Hubbard, R.E., Hoogewerf, A.J., and Wells, T.N.  Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses.   Biochemistry.  39:12959-68, 1999.  
  • Kuschert, G.S.V., Hoogewerf, A.J., Proudfoot, A.E.I., Chung, C-W., Cooke, R.M., Hubbard, R.E., Wells, T.N.C., and Sanderson, P.N.  Identification of a glycosaminoglycan binding surface on IL-8.  Biochemistry.  37:11193-11201, 1998.
  • Hoogewerf, A.J., Kuschert, G.S.V., Proudfoot, A.E.I., Borlat, F., Clark-Lewis, I., , and Wells, T. N. C.  Glycosaminoglycans Mediate Cell Surface Oligomerization of Chemokines.   Biochemistry.  36:13570-13578, 1997. 
  • Plater-Zyberk, C., Hoogewerf A.J., Proudfoot, A.E.I.,  , and Wells, T.N.C.  Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice. Immunology Letters. 57:117-120, 1997. 
  • Kuschert, G.S.V., Hubbard, R.E., , Wells, T.N.C., and Hoogewerf, A.J.  A Solid Phase Binding Assay to Study the Interaction of Chemokines with Glycosaminoglycans.  Methods Enzymol.  287:369-378, 1997. 
  • Bronke, C., Smith, D.A., Wells, T.N.C., Power, C.A., Hoogewerf, A.J., Ehlers, S., and Bancroft, G.J.  Chemokine receptors in granuloma formation during mycobacterial infection. Immunology Letters.  56:1-3, 1997. 
  • Proudfoot, A.E.I., Power, C.A., Hoogewerf, A.J., Montjovent, M.-O., Borlat, F., Offord, R.E., and Wells, T.N.C.  Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.  J. Biol. Chem.  271:2599-2603, 1996. 
  • Wells, T. N. C., Proudfoot, A. E. I., Power, C. A., Lusti-Narasimhan, M., Alouani, S., Hoogewerf, A. J., and Peitsch, M. C.  The molecular basis of the chemokine/chemokine receptor interaction -- scope for design of chemokine antagonists.  Methods.  10:126-134, 1996. 
  • Hoogewerf, A.J., Black, D., Proudfoot, A.E.I., Wells, T.N.C., and   Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to human and murine CC CKR-4.  Biochem. Biophys. Res. Comm.  218:337-343, 1996. 
  • Wells, T.N.C., , Lusti-Narasimhan, M., Hoogewerf, A.J., Cooke, R., Chung, C-W., Peitsch, M.C., and Proudfoot, A.E.I.  Selectivity and antagonism of chemokine receptors.  J. Leukoc. Biol.  59:53-60, 1996. 
  • Proudfoot, A.E.I., Power, C.A., Hoogewerf, A.J., Montjovent, M.-O., Borlat, F., and Wells, T.N.C.  Characterisation of the CC-Chemokine Receptor-1 (CC-CKR-1) stably transfected in HEK-293 cells.   FEBS Letters 376:19-23, 1995. 
  • Power, C.A., Meyer, A., Nemeth, K., Bacon, K.B., Hoogewerf, A.J., Proudfoot, A.E.I., and Wells, T.N.C.  Molecular cloning and functional expression of a novel C-C chemokine receptor cDNA from a human basophilic cell line.  J. Biol. Chem.  270:19495-19500, 1995. 
  • Hoogewerf, A.J., Leone, J.W., Reardon, I.M., Howe, W.J., Asa, D., Heinrikson, R.L., and Ledbetter, S.R.  CXC chemokines CTAP-III and NAP-2 are heparin/heparan sulfate degrading enzymes.  J. Biol. Chem.  270:3268-3277, 1995. 
  • Yeo, K.-T., Wang H.H., Nagy, J.A., Sioussat, T.M., Hoogewerf, A.J., Ledbetter, S.R., Zhou, Y., Senger, D.R., Dvorak, H.F., Yeo, T.-K.  Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human ascites fluid.  Cancer Res.  53:2912-2918, 1993. 
  • Hoogewerf, A.J., Cisar, L.A., Evans, D.C., and Bensadoun, A.  Effect of chlorate on the sulfation of lipoprotein lipase and heparan sulfate proteoglycans:  sulfation of heparan sulfate proteoglycans affects lipoprotein lipase degradation.  J. Biol. Chem.  266:16564-16571, 1991. 
  • Hoogewerf, A.J., and Bensadoun, A.  Occurrence of sulfate in an asparagine-linked oligosaccharide of chicken lipoprotein lipaseJ. Biol. Chem.  266:1048-1057, 1991. 
  • Cisar, L.A., Hoogewerf, A.J., Cupp, M., Rapport, A., and Bensadoun, A.  Secretion and degradation of lipoprotein lipase in cultured adipocytes:  binding of lipoprotein lipase to membrane heparan sulfate proteoglycans is necessary for degradationJ. Biol. Chem264:1767-1774, 1989. 


  • Principal investigator on Scholarship and Christianity in Oxford/John Templeton Foundation grant: Supporting Structure:  Innovative Collaborations to Enhance STEM Research at CCCU Member Institutions.  $192,379; 2021-2024. 
  • Co-PI on NSF S-STEM grant:  "Building Foundations for Undergraduate Success in STEM.”  Carolyn Anderson, Victor Norman, Michael D. Bolt, Arlene J. Hoogewerf, Herbert R. Fynwever.  $999,814; 2019-2024.                             
  • SAFI and SafeWater Drops.  Funds for faculty/student stipends and supplies for investigations on the effect of SAFI antimicrobial agents on bacteria.  ~$15,000; 2011-2013.  
  • Co-investigator on Merck/AAAS Undergraduate Science Research Program Grant to Calvin College Departments of Biology and Chemistry and Biochemistry.  Award:  $60,000; 2007-2009.   
  • Prinicipal Investigator on Beckman Coulter, Inc. Genomics Educational Matching Grant entitled “Acquisition of a Capillary Electrophoresis DNA Sequencer.”  $49,500; August 2007. 
  • Prinicipal investigator on NIH AREA Grant 1 R15 AI070179-01 entitled “Identification of Biofilm-Induced Staphylococcus aureus Cytokine Receptors.”  Award:  $199,529; 2006-2009. 
  • Co-investigator on NSF Grant DBI-0421120 entitled "Acquisition of a Fluorescence Microscope and Imaging System for Faculty Research and Undergraduate Research Training." Award: $174,298; August 2004. 
  • Co-investigator on NSF Grant DBI-0321049 entitled “Acquisition of a Flow Cytometer for Cell Biology Research and Undergraduate Research Training.”  Award: $224,934; July 2003. 
  • Co-investigator on Merck/AAAS Undergraduate Science Research Program Grant to Calvin College Departments of Biology and Chemistry and Biochemistry.  Award:  $60,000; 2003-2005.   
  • American Society for Microbiology 2001 Undergraduate Faculty Enhancement Program Award.  Award:  $750 in travel expenses and fees. 
  • NIH Postdoctoral Training Grant (1991)  
  • Quillman Fellowship, Cornell University (1990)  
  • Liberty Hyde Bailey Graduate Research Assistantship, Cornell University (1986-1990)  

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