Michael R Barbachyn


Education

  • B.A., Chemistry, Calvin College, 1979
  • Ph.D., Organic Chemistry, Wayne State University, 1983
  • NIH Postdoctoral Fellow, Yale University, 1983-1985

Thesis: β-Hydroxysulfoximine-Directed Cyclopropanations and Osmylations
Advisor: Dr. Carl R. Johnson

 

Professional experience

  • Brummel Professor of Chemistry, Calvin College, 2012-present
  • Director, Infection Discovery, AstraZeneca, Waltham, MA, 2007-2012
  • Director, Antibacterial Chemistry, Pfizer, Ann Arbor, MI, 2003-2007
  • Associate Director, Medicinal Chemistry, Pharmacia, Kalamazoo, MI, 2000-2003
  • Group Leader, Hepatitis C Project, Bristol-Myers Squibb, Wallingford, CT, 1998-1999
  • Scientist I-IV, The Upjohn Company and Pharmacia and Upjohn, Kalamazoo, MI, 1985-1998

Academic interests

  • Development of novel synthetic methodology
  • Identification of unique bioisosteres with applicability in pharmaceutical agents
  • Design and preparation of novel anti-infective agents with activity against multidrug-resistant pathogens

Courses taught

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Research and scholarship

Publications

Anderson, D. J.; Banitt, L. S.; Barbachyn, M. R.; et al. manuscript submitted to Antimicrobial Agents and Chemotherapy, 2013.  “Structure-Activity Relationships of Quinoline Pyrimidine Trione (QPT) Antibacterials.”

Barbachyn, M. R.; In Antibiotic Discovery and Development; Dougherty, T. J.; Pucci, M. J.; Eds.; Springer, 2011; Volume 1, Chapter 8. “Oxazolidinone Antibacterial Agents.”

Shaw, K.; Barbachyn, M. R.; Annals of the New York Academy of Sciences, 2011, 1241, 48-70.  “The Oxazolidinones: Past, Present and Future.”

Starr, J. T.; Sciotti, R. J.; Hanna, D. L.; Huband, M. D.; Mullins, L. M.; Cai, H.; Gage, J. W.; Lockard, M.; Rauckhorst, M. R.; Owen, R. M.; Lall, M. S.; Tomilo, M.; Chen, H.; McCurdy, S. P.; Barbachyn, M. R.; Bioorganic & Medicinal Chemistry Letters,2009, 19, 5302-5306.  “5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are Antibacterial Agents Targeting the ATPase Domains of DNA GyrAse and Topoisomerase IV.”

Ruble, J. C.; Hurd, A. R.; Johnson, T. A.; Sherry, D. A.; Barbachyn, M. R.; Toogood, P. L.; Bundy, G. L.; Graber, D. R.; Kamilar, G. M.  Journal of the American Chemical Society, 2009, 130, 3991-3997.  “Synthesis of (-)-PNU-286607 by Asymmetric Cyclization of Alkylidene Barbiturates.”

Barbachyn, M. R.; “Recent Advances in the Discovery of Hybrid Antibacterial Agents.” In Annual Reports in Medicinal Chemistry, Vol. 43; Macor, J. E., Primeau, J. Eds.; Elsevier:  London, UK, 2008; pp 281-290.

Miller, A. A.; Bundy, G. L.; Mott, J. E.; Skepner, J. E.; Boyle, T. P.; Harris, D. W.; Hromockyj, Marotti, K. R.; Zurenko, G. E.; Munzner, J. B.; Sweeney, M. T.; Bammert, G. F.; Hamel, J. C.; Ford, C. W.; Zhong, W.-Z.; Graber, D. R.; Martin, G. E.; Han, F.; Dolak, L. A.; Seest, E. P.; Ruble, J. C.; Kamilar, G. M.; Palmer, J. R.; Banitt, L. S.; Hurd, A. R.; Barbachyn, M. R.;  Antimicrobial Agents and Chemotherapy, 2008, 52, 2806-2812.  “Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors.”

Brickner, S. J.; Barbachyn, M. R.; Hutchinson, D. K.; Manninen, P. R.; Journal of Medicinal Chemistry, 2008, 51, 1981-1990.  “Linezolid (ZYVOXâ), the First Member of a Completely New Class of Antibacterial Agents for Treatment of Serious Gram-Positive Infections.”

Poel, T.-J.; Thomas, R. C.; Adams, W. J.; Aristoff, P. A.; Barbachyn, M. R.; Boyer, F. E.; Brieland, J.; Brideau, R.; Brodfuehrer, J.; Brown, A. P.; Choy, A. L.; Dermyer, M.; Dority, M.; Ford, C. W.; Gadwood, R. C.; Hanna, D.; Hongliang, C.; Huband, M. D.; Huber, C.; Kelly, R.; Kim, J.-Y.; Martin, J. P., Jr.; Pagano, P. J.; Ross, D.; Skerlos, L.; Sulvik, M. A.; Zhu, T.; Zurenko, G. E.; Prasad, J. V. N.  Journal of Medicinal Chemistry, 2007, 50, 5886-5889.  “Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain.  (5R)-trans-3-[3-Fluoro-4-(1-oxotetrahydrothiopyran-4-yl)phenyl]-2-oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound.”

Perrault, W. R.; Pearlman, B. A.; Godrej, D. B.; Jeganathan, A.; Yamagata, K.; Chen, J. J.; Lu, C. V.; Herrinton, P. M.; Gadwood, R. C.; Chan, L.; Dorow, R. L.; Lyster, M. A.; Maloney, M. T.; Moeslein, J. A.; Greene, M. L.; Barbachyn, M. ROrganic Process Research and Development, 2003, 7, 533-546.  "The Synthesis of N-aryl-5(S)-aminomethyl-2-oxazolidinone Antibacterials and Derivatives in one step from Aryl Carbamates."

Ciske, F. L.; Barbachyn, M. R.; Genin, M. J.; Grega, K. C.; Lee, C. S.; Dolak, L. A.; Seest, E. P.; Watt, W.; Adams, W. J.; Friis, J. M.; Ford, C. W.; Zurenko, G. E.; Bioorganic & Medicinal Chemistry Letters, 2003, 13, 4235-4239.  "The Potentiating Effect of Remote Chirality on the Antibacterial Activity of Indolinyl, Tetrahydroquinolyl and Dihydrobenzoxazinyl Oxazolidinones."

Gordeev, M. F.; Hackbarth, C.; Barbachyn,  M. R.; Banitt, L. S.; Gage, J. R.; Luehr, G. W.; Gomez, M.; Trias, J.; Morin, S. E.; Zurenko, G. E.; White, R. J.; Patel, D. V.; Bioorganic & Medicinal Chemistry Letters, 2003, 13, 4213-4216.  "Novel Oxazolidinone-Quinolone Hybrid Antimicrobials."

Barbachyn, M. R.; Cleek, G. J.; Dolak, L. A.; Garmon, S. A.; Morris, J.; Seest, E. P.; Thomas, R. C.; Toops, D. S.; Watt, W.; Wishka, D. G.; Ford, C. W.; Zurenko, G. E.; Hamel, J. C.; Schaadt, R. D.; Stapert, D.; Yagi, B. H.; Adams, W. J.; Friis, J. M.; Slatter, J. G.; Sams, J. P.; Oien, N. L.; Zaya, M. J.; Wienkers, L. C.; Wynalda, M. A.;  Journal of Medicinal Chemistry, 2003, 46, 284-302.  “The Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active Against Gram-Positive Pathogens.”

Barbachyn, M. R.; Ford, C. W.;  Angewandte Chemie International Edition, 2003, 42, 2010-23.  "Oxazolidinone Structure-Activity Relationships Leading to Linezolid."

Ford, C. W.; Zurenko, G. E.; Barbachyn, M. RCurrent Drug Targets, 2001, 1, 19-36.  “The Discovery of Linezolid, the First Oxazolidinone Antibacterial Agent.”

Lee, C.-S.; Allwine, D. A.; Barbachyn, M. R.; Dolak, L. A.; Grega, K. C.; Ford, C. W.; Jensen, R. M.; Seest, E. P.; Zurenko, G. E.; Hamel, J. C.; Schaadt, R. D.; Stapert, D.; Yagi, B. H.; Genin, M. J.; Bioorganics & Medicinal Chemistry, 2001, 9, 3243-3253. “Carbon-Carbon-Linked (Pyrazolylphenyl)oxazolidinones with Antibacterial Activity Against Multiple Drug Resistant Gram-Positive and Fastidious Gram-Negative Bacteria.”

Genin, M. J.; Allwine, D. A.; Anderson, D. J.; Barbachyn, M. R.; Emmert, E.; Garmon, S. A.; Graber, D. R.; Grega, K. C.; Hester, J. B.; Hutchinson, D. K.; Morris, J.; Reischer, R. J.; Ford, C. W.; Zurenko, G. E.; Hamel, J. C.; Schaadt, R. D.; Stapert, D.; Yagi, B. H.; Journal of Medicinal Chemistry, 2000, 43, 953.  “Substituent Effects on the Antibacterial Activity of Nitrogen-Carbon Linked Azolylphenyl Oxazolidinones with Expanded Activity Against the Fastidious Gram-Negative Organisms Haemophilus influenzae and Moraxella catarrhalis.”

Ford, C. W.; Hamel, J.; Stapert, D.; Moerman, J.; Hutchinson, D.; Barbachyn, M.; Zurenko, G.; Infections in Medicine, 1999, 16, 43.  “Oxazolidinones: A New Class of Antimicrobials.”

Barbachyn, M. R.; Brickner, S. J.; Gadwood, R. C.; Garmon, S. A.; Grega, K. C.; Hutchinson, D. K.; Munesada, K.; Reischer, R. J.; Taniguchi, M.; Thomasco, L. M.; Toops, D. S.; Yamada, H.; Ford, C. W.; Zurenko, G. E.;  Advances in Experimental Medicine and Biology, 1998, 456, 219-38.  “Design, synthesis, and evaluation of novel oxazolidinone antibacterial agents active against multidrug-resistant bacteria.”

Barbachyn, M. R.; Brickner, S. J.; Gadwood, R. C.; Garmon, S. A.; Hutchinson, D. K.; Grega, K. C.; Munesada, K.; Reischer, R. J.; Taniguchi, M.; Thomasco, L. M.; Toops, D. S.; Yamada, H.; Ford, C. W.; Zurenko, G. E.; In Resolving the Antibiotic Paradox; Rosen, B. P., Mobashery, S., Eds.; Kluwer Academic/Plenum: New York, 1998; Vol. 456, Chapter 12. “Design, Synthesis, and Evaluation of Novel Oxazolidinone Antibacterial Agents Active Against Multidrug-Resistant Bacteria.”

Tucker, J. A.; Allwine, D. A.; Grega, K. C.; Barbachyn, M. R.; Klock, J. L.; Adamski, J. L.; Brickner, S. J.; Hutchinson, D. K.; Ford, C. W.; Zurenko, G. E.; Conradi, R. A.; Burton, P. S.; Jensen, R. M.; Journal of Medicinal Chemistry, 1998, 41, 3727.  “Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazine, or Triazine Heteroaromatic Ring.”

Ford, C. W.; Hamel, J. C.; Stapert, D.; Moerman, J. K.; Hutchinson, D. K.; Barbachyn, M. R.; Zurenko, G. E.; Trends in Microbiology: Virulence, Infection and Pathogenesis, 1997, 5, 196.  “Oxazolidinones: New Antibacterial Agents.”

Zurenko, G. E.; Ford, C. W.; Hutchinson, D. K.; Brickner, S. J.; Barbachyn, M. R. Expert Opinion on Investigational Drugs, 1997, 6, 151.  “Oxazolidinone Antibacterial Agents; Development of the Clinical Candidates Eperezolid and Linezolid.”

Barbachyn, M. R.; Brickner, S. J.; Cleek, G. J.; Gadwood, R. C.; Grega, K. C.; Hendges, S. K.; Hutchinson, D. K.; Manninen, P. R.; Munesada, K.; Thomas, R. C.; Thomasco, L. M.; Toops, D. S.; Ulanowicz, D. A.  “Design and Synthesis of Novel Oxazolidinones Active Against Multidrug-Resistant Bacteria.” In Anti-Infectives: Recent Advances in Chemistry and Structure-Activity Relationships; Bentley, P. H., O'Hanlon, P. J., Eds.; The Royal Society of Chemistry:  Cambridge, UK, 1997; pp 15-26.

Ford, C. W.; Hamel, J. C.; Wilson, D. M.; Moerman, J. K.; Stapert, D.; Yancey, R. J., Jr.; Hutchinson, D. K.; Barbachyn, M. R.; Brickner, S. J.; Antimicrobial Agents and Chemotherapy, 1996, 40, 1508.  “In Vivo Activity of U-100592 and U-100766, Novel Oxazolidinone Antimicrobial Agents, Against Experimental Bacterial Infections.”

Zurenko, G. E.; Yagi, B. H.; Schaadt, R. D.; Allison, J. W.; Kilburn, J. O.; Glickman, S. E.; Hutchinson, D. K.; Barbachyn, M. R.; Brickner, S. J.; Antimicrobial Agents and Chemotherapy, 1996, 40, 839.  “In Vitro activity of U-100592 and U-100766, Novel Oxazolidinone Antibacterial Agents.”

Barbachyn, M. R.; Toops, D. S.; Grega, K. C.; Hendges, S. K.; Ford, C. W.; Zurenko, G. E.; Hamel, J. C.; Schaadt, R. D.; Stapert, D.; Yagi, B. H.; Buysse, J. M.; Demyan, W. F.; Kilburn, J. O.; Glickman, S. E.; Bioorganic & Medicinal Chemistry Letters, 1996, 6, 1009.  “Synthesis and Antibacterial Activity of New Tropone-Substituted Phenyloxazolidinones.  2.  Modification of the Phenyl Ring - the Potentiating Effect of Fluorine Substitution on In Vivo Activity.”

Barbachyn, M. R.; Toops, D. S.; Ulanowicz, D. A.; Grega, K. C.; Brickner, S. J.; Ford, C. W.; Zurenko, G. E.; Hamel, J. C.; Schaadt, R. D.; Stapert, D.; Yagi, B. H.; Buysse, J. M.; Demyan, W. F.; Kilburn, J. O.; Glickman, S. E.; Bioorganic & Medicinal Chemistry Letters, 1996, 6, 1003.  “Synthesis and Antibacterial Activity of New Tropone-Substituted Phenyloxazolidinones.  1.  Identification of Leads and Importance of the Tropone Substitution Pattern.”

Barbachyn, M. R.; Hutchinson, D. K.; Brickner, S. J.; Cynamon, M. H.; Kilburn, J. O.; Klemens, S. P.; Glickman, S. E.; Grega, K. C.; Hendges, S. K.; Toops, D. S.; Ford, C. W.; Zurenko, G. E.; Journal of Medicinal Chemistry, 1996, 39, 680.  “Identification of a Novel Oxazolidinone (U-100480) with Potent Antimycobacterial Activity.”

Brickner, S. J.; Hutchinson, D. K.; Barbachyn, M. R.; Manninen, P. R.; Ulanowicz, D. A.; Garmon, S. A.; Grega, K. C.; Hendges, S. K.; Toops, D. S.; Ford, C. W.; Zurenko, G. E.; Journal of Medicinal Chemistry, 1996, 39, 673.  “Synthesis and Antibacterial Activity of U-100592 and U-100766, Two Oxazolidinone Antibacterial Agents for the Potential Treatment of Multidrug-Resistant Gram-Positive Bacterial Infections.”

Grega, K. C.; Barbachyn, M. R.; Brickner, S. J.; Mizsak, S. A.; Journal of Organic Chemistry, 1995, 60, 5255.  “Regiospecific Metalation of Fluoroanilines: an Application to the Synthesis of Fluorinated Oxazolidinone Antibacterial Agents.”

Barbachyn, M. R.  “Cerium (III) Acetate-Boron Trifluoride Etherate.”  In Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed.; John Wiley & Sons, Inc.: New York, 1994.

Toops, D. S.; Barbachyn, M. R.; Journal of Organic Chemistry, 1993, 58, 6505.  “Efficient Synthesis of 1-(Trialkylstannyl)- and 1-(Triarylstannyl) bicyclo[1.1.1] pentanes.”

Barbachyn, M. R.; Hutchinson, D. K.; Toops, D. S.; Reid, R. J.; Zurenko, G. E.; Yagi, B. H.; Schaadt, R. D.; Allison, J. W.; Bioorganic & Medicinal Chemistry Letters, 1993, 3, 671. “U-87947E, a Potent Quinolone Antibacterial Agent Incorporating a Bicyclo[1.1.1]pent-1-yl (BCP) Subunit.”

Barbachyn, M. R.; Tuominen, T. C.; Journal of Antibiotics 1990, 43, 1199.  “Synthesis and Structure-Activity Relationships of Monocarbams Leading to U-78608.”

Danishefsky, S. J.; DeNinno, S. L.; Chen, S.-H.; Boisvert, L.; Barbachyn, M. R.; Journal of the American Chemical Society, 1989, 111, 5810.  “Fully Synthetic Stereoselective Routes to the Differentially Protected Subunits of the Tunicamycins.”

Danishefsky, S. J.; Barbachyn, M. R., Journal of the American Chemical Society,1985, 107, 7761.  “A Fully Synthetic Route to Tunicaminyluracil.”

Johnson, C. R.; Barbachyn, M. R.; Meanwell, N. A.; Stark, C. J., Jr.; Zeller, J. R.; Phosphorous and Sulfur, 1985, 24, 151-163.  “Utilization of Sulfoximines in the Synthesis of Optically Pure Substances.”

Barbachyn, M. R.; Johnson, C. R.  “Optical Activation and Utilization of Compounds Containing Chiral Sulfur Centers.”  In Asymmetric Synthesis; Morrison, J. D.; Education Academic Press: New York, 1984; Vol. 4, Chapter 2.

Danishefsky, S. J.; Maring, C. J.; Barbachyn, M. R.; Segmuller, B. E.; Journal of Organic Chemistry, 1984, 49, 4564.  “An Approach to the Synthesis of Carbon-Carbon Linked Disaccharides.”

Johnson, C. R.; Barbachyn, M. R.; Journal of the American Chemistry Society, 1984, 106, 2459.  “Sulfoximine-Directed Osmylation:  Synthesis of Enantiomerically Pure Dihydroxycycloalkanones.”

Barbachyn, M. R.; Johnson, C. R.; Glick, M. D.; Journal of Organic Chemistry, 1984, 49, 2746.  “Synthesis and Absolute Configuration of (-)-Rothrockene, a Non-Head-to-Tail Monoterpene.”

Johnson, C. R.; Barbachyn, M. R.; Journal of the American Chemistry Society, 1982, 104, 4290.  “β-Hydroxysulfoximine-Directed Simmons-Smith Cyclopropanations.  Synthesis of (-)- and (+)-Thujopsene.”

DeKock, R. L.; Barbachyn, M. R.; Journal of Inorganic and Nuclear Chemistry, 1981, 43, 2645.  “Electronic Structure and Molecular Topology of Boron and Aluminum Suboxides.”

DeKock, R. L.; Barbachyn, M. R.; Journal of the American Chemistry Society, 1979, 101, 6516-6519.  “Proton affinity Ionization Energy, and the Nature of Frontier Orbital Electron Density.”

Patents

Additional patent applications pending. 

Thomas, R. C; Poel, T.-J.; Barbachyn, M. R.; Gordeev, M. F.; et al. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives.  U.S. 7,645,781, January 12, 2010.

Barbachyn, M. R.; Ruble, J. C.; Romero, A. G.; Thomasco, L. N.; Hurd, A. R.; et al. Tricyclic tetrahydroquinoline antibacterial agents.  U.S. 7,605,157, October 20, 2009.

Barbachyn, M. R.; Bundy, G. L.; et al. Tricyclic Tetrahydroquinoline Antibacterial Agents.  U.S. 7,208,490, April 24, 2007.

Thomas, Richard C.; Poel, Toni-jo; Barbachyn, Michael R.; Gordeev, Mikhail F.; Luehr, Gary W.; Renslo, Adam; Singh, Upinder.  U.S. 6,919,329, July 19, 2005.

Gordeev; Mikhail F.; Patel; Dinesh V.; Barbachyn; Michael R.; Gage; James R. U.S. 6,869,965, March 22, 2005.

Genin, M. J.; Barbachyn, M. R.; Hester, Jr., J. B.; Johnson, P. D.; Ciske, F. L.  U.S. 6,825,225, November 30, 2004.

Gordeev, M. F.; Patel, D. V.; Barbachyn, M. R.; Gage, J. R.  U.S. 6,689,769, February 10, 2004.

Barbachyn, M. R. A Thiazine Oxazolidinone.  U.S. 6,605,609, August 12, 2003.

Barbachyn, M. R.; Genin, M. J.; Hester, J. B., Jr.; Johnson, P. D.  Bicyclic Oxazolidinones as Antibacterial Agents.  U.S. 6,387,896, May 14, 2002.

Barbachyn, M. R.; Homa, F. L.; Monge, A.; Santiago, E.; Martinez-Irujo, J. J.; Font, M.  Polyaromatic Antiviral Compositions. U.S. 6,147,116, November 14, 2000.

Barbachyn, M. R.; Thomas, R. C.; Cleek, G. J.  Isoxazoline Derivatives Useful as Antimicrobials.  U.S. 6,093,736, July 25, 2000.

Barbachyn, M. R.; Brickner, S. J.; Hutchinson, D. K.  Spirocyclic and Bicyclic Diazinyl and Carbazinyl Oxazolidinones.  U.S. 6,090,820, July 18, 2000.

Poel, T. J.; Martin, J. P., Jr.; Barbachyn, M. R.  S-Oxide and S,S-Dioxide Tetrahydrothiopyran Phenyloxazolidinones.  U.S. 6,083,967, July 4, 2000.

Barbachyn, M. R.; Morris, J.; Wishka, D. G.; Cleek, G. J.; Thomas, R. C.  Substituted Aminophenyl Isoxazoline Derivatives Useful as Antimicrobials.  U.S. 6,069,141, May 30, 2000.

Barbachyn, M. R.; Cleek, G. J.; Thomas, R. C.  Isoxazoline Derivatives Useful as Antimicrobials.  U.S. 5,990,136, November 23, 1999.

Thomas, R. C.; Poel, T. J.; Barbachyn, M. R.  Phenyloxazolidinones Having a C-C Bond to 4-8 Membered Heterocyclic Rings.  U.S. 5,968,962, October 19, 1999.

Barbachyn, M. R.; Homa, F. L.; Monge, A.; Santiago, E.; Martinez-Irujo, J. J.; Font, M.  Polyaromatic Antiviral Compositions. U.S. 5,958,983, September 28, 1999.

Barbachyn, M. R.; Thomas, R. C.; Cleek, G. L.; Thomasco, L. M.; Gadwood, R. C. Bicyclic Oxazine and Thiazine Oxazolidinone Antibacterials.  U.S. 5,952,324, September 14, 1999.

Barbachyn, M. R.; Brickner, S. J. Substituted Heteroarylphenyloxazolidinones.  U.S. 5,929,248, July 27, 1999.

Hutchinson, D. K.; Brickner, S. J.; Barbachyn, M. R.; Taniguchi, M.; Munesada, K.; Yamada, H.  Phenyloxazolidinone Antimicrobials.  U.S. 5,883,093, March 16, 1999.

Barbachyn, M. R.; Hutchinson, D. K.; Brickner, S. J.  Substituted Oxazine and Thiazine Oxazolidinone Antimicrobials.  U.S. 5,880,118, March 9, 1999.

Pearlman, B. A.; Perrault, W. R.; Barbachyn, M. R.; Manninen, P. R.; Toops, D. S.; Houser, D. J.; Fleck, T. J.  Process to Prepare Oxazolidinones.  U.S. 5,837,870, November 17, 1998.

Barbachyn, M. R.; Brickner, S. J. Substituted Heteroarylphenyloxazolidinones.  U.S. 5,801,246, September 1, 1998.

Barbachyn, M. R.; Brickner, S. J. Substituted Heteroarylphenyloxazolidinones.  U.S. 5,756,732, May 26, 1998.

Gadwood, R. C.; Barbachyn, M. R.; Toops, D. S.; Smith, H. W.; Vaillancourt, V. A.  Azolyl Piperazinyl Phenyl Oxazolidinone Antimicrobials.  U.S. 5,736,545, April 7, 1998.

Hester, J. B.; Brickner, S. J.; Barbachyn, M. R.; Hutchinson, D. K.; Toops, D. S.  5-Amidomethyl a,b-Saturated and Unsaturated 3-Aryl Butyrolactone Antibacterial Agents.  U.S. 5,708,169, January 13, 1998.

Hutchinson, D. K.; Barbachyn, M. R.; Brickner, S. J.; Gammill, R. B.; Patel, M. V. Oxazolidinone Antimicrobials Containing Substituted Diazine Moieties.  U.S. 5,700,799, December 23, 1997.

Barbachyn, M. R.; Brickner, S. J. Substituted Aryl- and Heteroarylphenyloxazolidinones.  U.S. 5,654,435, August 5, 1997.

Barbachyn, M. R.; Brickner, S. J. Substituted Aryl- and Heteroarylphenyloxazolidinones.  U.S. 5,654,428, August 5, 1997.

Brickner, S. J.; Barbachyn, M. R.; Hutchinson, D. K.  Esters of Substituted Hydroxyacetyl Piperazine Phenyl Oxazolidinones.  U.S. 5,652,238, July 29, 1997.

Barbachyn, M. R.; Brickner, S. J. Substituted Aryl- and Heteroarylphenyloxazolidinones.  U.S. 5,565,571, October 15, 1996.

Hutchinson, D. K.; Barbachyn, M. R.; Brickner, S. J.; Gammill, R. B.; Patel, M. V. Oxazolidinone Antimicrobials Containing Substituted Diazine Moieties.  U.S. 5,547,950, August 20, 1996.

Barbachyn, M. R.  Tropone-Substituted Phenyloxazolidinone Antibacterial Agents.  U.S. 5,523,403, June 4, 1996.

Gammill, R. B.; Bisaha, S. N.; Timko, J. M.; Judge, T. M.; Barbachyn, M. R.; Kim, K. S.  Antibacterial Quinolone Compounds.  U.S. 5,385,906, January 31, 1995.

Barbachyn, M. R.  Novel N-1 Substituted b-Lactams as Antibiotics.  U.S. 5,006,650, April 9, 1991.

Barbachyn, M. R., Brickner, S. J., Thomas, R. C.  Antibiotic Sulfonylaminocarbonyl Activated b-Lactams.  U.S. 4,975,538, December 4, 1990.

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