A close up of the human eye.

  • Friday, November 1, 2019
  • 1:30 PM–2:30 PM
  • Science Building 010

Abnormal Development of the Retina and Reduced Bone Mass in Rats Deficient in Lrp5: A Human Disease Model Developed Using CRISPR/Cas9 Guest Speaker: John Ubels- Calvin University SB010 Friday, Nov. 1st, 2019 1:30p - 2:30p

The Wnt signaling pathway controls normal development of bone and retina. Loss of function mutations of the Wnt co-receptor, Lrp5, result in decreased bone mass and density and impaired development of the retinal blood vessels. In children this can result in osteoporosis by age 5 and blindness. Using CRISPR/cas9, we have developed a rat model of this disease in which bone pathology is very similar to humans. The retinal blood vessels are sparce and leaky, the retina is thin and the response to light is impaired. This rat model will be useful for understanding human Lrp5 mutations and the development of treatment that can restore Lrp5 function. Join us this week for the BIO295 "BioSem" session as we welcome Calvin's own Prof. John Ubels back to campus to lead us in this topic.  We would love to have you join us!

Location details

Science Building 010- located on the ground floor of the Science Building