An Alternative to Lewis-Acid Catalysis

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Mutagenesis studies have implicated an aromatic stack as the method of enzymatic activation for the purine salvage pathway in protozoa. Generation of a beta-haripin peptide with diagonally displayed tryptophan residues should mimic the binding pocket yielding glycosidic bond hydrolysis of adenosine

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Chad Tatko

Chad Tatko

Associate Professor
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